Massilia to Carthage is the route that involves trade outside of the Byzantine Empire.The Byzantine Empire was also known as the Eastern Roman Empire. Its capital city was Constantinople. The routes Rome to Athens, Alexandra to Ravenna and Antioch to Ephesus all fall within the Byzantine Empire. The Byzantine Empire was the most powerful empire during its existence and survive the breaking up and fall of the Western Roman Empire.
Bacon's Rebellion
Bacon's Rebellion was an armed rebellion in 1676 by Virginia settlers led by Nathaniel Bacon against the rule of Governor William Berkeley. About a thousand Virginians rebelled because they begrudged Governor Berkeley's friendly policies towards the Native Americans.
It was not quite a 100 years old yet but your close
The spread of Humankind to inhabit all the part of the Globe was a significant advancement in the Paleolithic age.
The Paleolithic Age is commonly known as the Stone Age, begun roughly 500,000 years ago and ended around 6000 B.C.E. People in this period produced complex tools and objects made out of stones. This age comprises the initial widespread use of technology as humans advanced from simplistic to a more complicated developmental stage and the spread of Humanity from the Savannas of East Africa to the rest of the world.
