Question

Choose the true statement. Receptor tyrosine kinases undergo autophosphorylation. G proteins phosphorylate receptor tyrosine kinases. Receptor tyrosine kinases include seven transmembrane segments. Active receptor tyrosine kinases are monomeric proteins.

Answer 1

Answer:

Receptor tyrosine kinases undergo autophosphorylation.

Explanation:

The receptor tyrosine kinases (RTKs) are proteins that undergo dimerization and autophosphorylation after binding with their corresponding ligands, thereby triggering downstream molecular signaling cascades. The RTKs bind with high specificity to ligands including growth factors, hormones and cytokines. In human cells, there are 58 types of RTKs proteins that function to regulate developmental pathways, and their dysfunctions have been associated with cancer progression.