Answer:
Answer is C.
Explanation:
For A and B, a base substitution affects one of the three bases that comprise a codon, the DNA/RNA unit that corresponds to a particular amino acid. If one base is substituted, one codon and therefore one amino acid will be affected. Codons have built-in redundancy, so even by changing one base, the new codon sometimes still corresponds to the same amino acid. Therefore, a base substitution at most affects one amino acid, and sometimes doesn't affect it all.
Frameshift mutations cause a lot more trouble. These occur when you have a deletion or insertion that changes the number of bases in your gene. As a result, the "frame" of the codons changes (everything shifts one way or the other by the number of bases added/removed). This affects EVERY codon downstream of the mutation, so you can imagine that such a mutation would have a bigger effect the closer to the start of the gene it occurs. This is why C is correct.
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Answer:
Option-1 and 3
Explanation:
Cadherin is the protein complex present in the cell which is responsible for the sticking together of cell in tissue-like in the skin. The cadherin junctions allow the communication between the cells and the loss of the cadherin could cause cancer.
The cadherin junction is involved in the signalling pathway in the cells like in the Rho GTPase signalling, Ras signalling and many others which shows that they are responsible for the biological processes in an organism.
Thus, Option-1 and 3 are correct.