Question

Hemophilia is a disease that causes uncontrollable bleeding. If a father has it, all of his daughters will be carriers of the disease, and about half of his sons will have the disease. An error in which macromolecule is the cause of hemophilia?

Answer 1

Answer:

The correct answer would be nucleic acid or DNA.

It is an X-linked recessive disorder which is caused by a mutation in the gene present on X chromosome.

This mutated allele produced non-functional protein (clotting factor) due to which blood does not clot efficiently.

Consequently, the blood flows for longer time than normal.

Answer 2

Hemophilia is caused by a defect in the genes responsible for the formation of blood clotting factors viii and ix. These genes are located on the X chromosome. A female has two X chromosomes and a male has an X chromosome and a Y chromosome. Therefore, all the daughters of a hemophiliac father will be the carriers of this disease, and half of his sons acquiring the X chromosome from the father will have the disease.