During transcription, enzymes bind to a molecule of DNA. Then, the enzymes unwind and separate the DNA's double helical strands.
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The mutation is a change in the nucleotidic sequence. In the exposed example, Patient 1: nucleotide 143, T<u>T</u>C⇒T<u>G</u>C. Patient 2: nucleotide 143, T<u>T</u>C⇒T<u>C</u>C. Patient 3: nucleotide 147, TT<u>C</u> ⇒ TT<u>G</u>.
<h3>What is a mutation?</h3>
A mutation is a change or alteration in DNI sequences that introduce new variants.
Many of these are eliminated, but some of them might succeed and be incorporated into each individual.
These mutations are the ones that have been selected by natural selection.
<h3>Solving the problem</h3>We know that each sequence initiates with nucleotide number 103 and ends in nucleotide 162.
So first, we will number the nucleotides, from 103 to 162. Each nucleotide has a number in increasing order.
Now, we will identify the mutations in each of the strands by comparing them with the wild-type sequence. The mutation occurs in one of the nucleotides, so we must look for the change in the bases.
Finally, we will identify the nucleotide location of each mutation.
nucleotide wild-type mutated
<u> location nucleotide nucleotide </u><u> </u>
Patient 1 143 TTC TGC
Patient 2 143 TTC TCC
<u>Patient 3 147 TTC TTG </u>
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In the attached files you will find an image for a better understanding.
You will learn more about mutations at
