The answer to your question is letter A
You can't actually take random words and make them a sentence because a sentence is a complete thought.You have to think about your sentence or else it won't make sense.
D it talks about how she was responsible for developing important drugs
Answer:
Impudence's meaning is not showing due respect for another person; impertinent, insolent. I highly doubt that a person who is impudent with others could ever cool off a tense situation. They would have to change their attitude towards others to be able to calm down.
For example, "the student is being impudent with his teacher".