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ahrayia [7]
3 years ago
10

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is

a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome?
A: duplication
B: Insertion
C.Inversion
D. substitution
E.translocation
Biology
2 answers:
ivolga24 [154]3 years ago
7 0
E; translocation, which is a chromosomal rearrangement in which a part of genetic material from one chromosome becomes heritably (genetically) tied to another chromosome.*

Sources:
*Definition of "Translocation" (Paraphrase):
http://www.dictionary.com/browse/translocation?s=t

The Philadelphia Chromosome:
https://www.medicinenet.com/script/main/art.asp?articlekey=4870
Elena L [17]3 years ago
5 0

Answer:

E.translocation

Explanation:

The chromosomal disorder CML is caused by reciprocal translocation between chromosome 9 and chromosome 22, in which rearrangement of chromosomes takes place.

Due to this rearrangement, part of chromosome 9 having ABL1 gene gets fused with part of chromosome 22 having BCR gene and resulting chromosome is known as Philadelphia chromosome.

ABL1-BCR fusion gene represents an oncogene that codes for a mutated protein that leads to unregulated cell division and impaired DNA binding and can cause cancer.

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