If I understand your question correctly, I believe it was the Ming Dynasty which lasted from 1338-1644.
Answer:
The Industrial Revolution would turn London into one of the world's first megacities as it grew the swallow up several parishes and areas that had once been farmland and created new demands on city services thanks to overcrowding.
In the slum areas of cities, diseases like cholera, typhus and diphtheria were endemic . Some could be linked to poor sanitation (cholera) and poor housing (TB) while others were spread by body lice (typhus). In addition, there were the new industrial diseases.
Children often had to work under very dangerous conditions. They lost limbs or fingers working on high powered machinery with little training. They worked in mines with bad ventilation and developed lung diseases.
It would be "the Environmental Protection Agency" that primarily deals with domestic policy issues, since this agency protects the environment of the United States.
Anti-Federalists argued that the Constitution gave too much power to the federal government, while taking too much power away from state and local governments. Many felt that the federal government would be too far removed to represent the average citizen.
Throughout the Middle Ages, Constantinople, capital of the Eastern Roman Empire (known as the Byzantine Empire), was the trade hub between the goods transported along the Silk Road all the way from China, and the Venetian and Genoese merchants. When Constantinople was conquered by the Ottomans by the force of arms, in 1453 A.D. they took over the control of all the trade coming through the Silk Road. However, they denied European merchantes access to Constantinople and the goods traded in that city which prompted the Portuguese to seek maritime routes to India and China sailing around the Western African coastline.
