The most impactful changes to Native American populations done by the colonial settlement was:
1 - the disease - <span>smallpox and influenza killed almost 90% American Native population 2. extermination policies - by hunting them, the population was in decline 3. Territory - the colonists took their land 4. forced relocation policies - the colonits forced them to stay in some special place, no leaving, starving them </span>5. coexistence reasoning - the differences between colonist and Native believes