The Skye-Picot agreement was the the agreement during world war one.
It is the excessive use of credit. The shares trading system crash of 1929 touched off a chain of occasions that dove the United States into its longest, most profound monetary emergency in its history. It is awfully shortsighted to see money markets crash as the single reason for the Great Depression. A solid economy can recuperate from such a compression.
The US Constitution was a radical departure from the Articles of Confederation to a great extent, since it established a powerful central government that had power over the individual states.
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