A. Predestination. John Calvin was a famous French theologian and a major leader of the Protestant Reformation. He helped popularize the belief in the sovereignty of God in all areas of life, as well as the doctrine of predestination.
After President Eisenhower withdrew his offer to fund the Aswan Dam, Egyptian President Nasser nationalized the Suez Canal.
A. Transcontinental railroad
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This is a bit subjective, but one could argue that the Fourteenth Amendment, which was one of the Reconstruction amendments, had the biggest impact on American history since it declared that all American citizens must have equal rights and protections under the law.