Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
She can give the example of Grains and legumes because when they combine we get all essential amino acids.
What are complementary Proteins ?
Protein complementation is most effecticient to get all 9 amino acids into a vegetarian diet. When combination of two vegetable protein takes place to get all 9 essential Amino acids for your body.
Grains and legumes , legumes and nuts , nuts and vegetables, vegetable and grains when they combine with we get all essential Amino acids like Tryptophan, lysine, valine ,threonine , phenylalanine, histidine , isoleucine, leucine are the Amino acids which are not produce in the body we have take it from outside.
to learn more about Complementary Protein click here brainly.com/question/28207757
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They are able to use imperatives and interrogatives.
They frequently use the auxiliary verb "have" in statements.
Answer:
i think its a.b.c.d.e.f.g.h.i.j
Explanation:
because they all have to be in one sentence.
Blood type A+ indicates the presence of Rh antigen on the red blood cells (specifically type A antigens with the presence of a protein called the Rhesus factor)
