Answer: Economically the population decrease brought by the Colombian exchange caused a drastic labor shortage throughout America, which lead to the estbalishment of African Slavery on a big scale in the americas.
It's, "We hold these truths to be self-evident "that all men are created equal, that they are endowed "by their Creator with certain unalienable Rights, "that among these are Life, Liberty, and the pursuit "of Happiness.
The answer is number one, proof.