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nignag [31]
4 years ago
8

The order of prosthetic groups as they act in the three proteins of the PDH (pyruvate dehydrogenase) complex is ________.

Biology
1 answer:
Alexxx [7]4 years ago
8 0

Answer:

The correct answer will be thiamine pyrophosphate (TPP) → dihydrolipoamide  → Flavin adenine dinucleotide (FAD).

Explanation:

The pyruvate dehydrogenase complex is a multi-functional enzyme which decarboxylates the pyruvate to form Acetyl CoA.  The complex consists of three catalytic enzymes which attach the non-protein part to its structure.

The prosthetic groups are the non-protein groups which bound strongly to the enzyme. In this complex the prothetic groups are :

1. Thiamine pyrophosphate (TPP)- attached to Pyruvate dehydrogenase (E1).

2. Lipoamide: attached to dihydrolipoyl transacetylase (E2).

3. Flavin adenine dinucleotide (FAD): attached to dihydrolipoyl dehydrogenase (E3).

These enzymes work in sequence: E1 →E2→ E3 therefore, the correct order of prosthetic group will be thiamine pyrophosphate (TPP) → dihydrolipoamide  → Flavin adenine dinucleotide (FAD). Thus, this is the correct order.

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