Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
Standardized Nursing Language
Explanation:
Identifying relevant information in medical conversations does help to summarize a clinician-patient encounter. This is a correct statement.
<h3>What is a clinician-patient encounter?</h3>
Patients are the center of modern healthcare discourse, where doctors "share power" equally in their interactions with patients. However, the research has not yet looked into how doctors really think about and control their authority while engaging with patients.
This study looked at how power is perceived and used in the doctor-patient relationship from the viewpoint of seasoned doctors. In the context of contemporary healthcare, which upholds principles of dialogic, egalitarian, and patient-centered care, it is vital to investigate physicians' understanding of power.
Therefore, this is a correct statement.
Read more about the clinician-patient encounters, here
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Answer:
Size and shape of the cell can help you determine healthy vs. non-healthy cells.
A normal cell also has a large cytoplasmic volume, with a controlled growth. The opposite is true for cancer cells.
Explanation:
The overall size and shape of cancer cells are often abnormal. They may be either smaller or larger than normal cells. Normal cells often have certain shapes that help them do their jobs. Cancer cells usually do not function in a useful way and their shapes are often distorted.
Answer:
<u>It's a fruit.</u>
Explanation: Helps keep you hydrated and is soaked with nutrients. Thanks for the points luv ^-^.
