Adenylate cyclases (ACs) are the membrane-bound glycoproteins that convert ATP to cAMP and pyrophosphate.
When activated by G-protein Gs, adenylate cyclases (ACs), which are membrane-bound glycoproteins, catalyze the synthesis of cAMP from ATP.
Different AC isoforms are widely expressed in various tissues that participate in regulatory systems in response to particular stimuli.
Humans have 9 different AC isoforms, with AC5 and AC6 thought to be particularly important for cardiac activities.
Nitric oxide has an impact on the activity of AC6, hence the protein's nitrosylation may control how it works. However, little is known about the structural variables that affect nitrosylation in ACs and how they relate to G's.
We predict the cysteines that are prone to nitrosylation using this 3D model, and we use virtual ligand screening to find potential new AC6 ligands.
According to our model, the AC-Gs interface's Cys174 in G's and Cys1004 in AC6 (subunit C2) are two potential residues that could experience reversible nitrosylation.
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ovary
These oocytes are formed during the early development of the person, it is together formed in the embryonic stage of development.
In puberty, these oocytes have now been mature thus, the individual is ready for her first menstruation, it takes time before these oocytes are fully developed but they are formed as early as the state of the genitalia, brain, body was formed.
<span>Somehow, it is like the brain, the brain is slowly developing til the near age of puberty or late childhood. </span>
<span>Eyes are also an analogy to oocytes, during infancy these organs aren't developed yet and these years the child can only see vague and blurred vision and takes almost 2 years for the child to see clearly.</span>
Increasing the temperature will cause an increase in the kinetic energy of molecules which will change its state to gas.
C It controls what is allowed to enter or leave the cell.
Hope this helps !! :) good luck
