The DNA polymerases are enzymes that create DNA molecules by assembling nucleotides, the building blocks of DNA. These enzymes are essential to DNA replication and usually work in pairs to create two identical DNA strands from one original DNA molecule. During this process, DNA polymerase “reads” the existing DNA strands to create two new strands that match the existing ones.
Every time a cell divides, DNA polymerase is required to help duplicate the cell’s DNA, so that a copy of the original DNA molecule can be passed to each of the daughter cells. In this way, genetic information is transmitted from generation to generation.
Before replication can take place, an enzyme called helicase unwinds the DNA molecule from its tightly woven form. This opens up or “unzips” the double stranded DNA to give two single strands of DNA that can be used as templates for replication.
DNA polymerase adds new free nucleotides to the 3’ end of the newly-forming strand, elongating it in a 5’ to 3’ direction. However, DNA polymerase cannot begin the formation of this new chain on its own and can only add nucleotides to a pre-existing 3'-OH group. A primer is therefore needed, at which nucleotides can be added. Primers are usually composed of RNA and DNA bases and the first two bases are always RNA. These primers are made by another enzyme called primase.
Although the function of DNA polymerase is highly accurate, a mistake is made for about one in every billion base pairs copied. The DNA is therefore “proofread” by DNA polymerase after it has been copied so that misplaced base pairs can be corrected. This preserves the integrity of the original DNA strand that is passed onto the daughter cells.

A surface representation of human DNA polymerase β (Pol β), a central enzyme in the base excision repair (BER) pathway. Image Credit: niehs.nih.gov
Structure of DNA polymerase
The structure of DNA polymerase is highly conserved, meaning their catalytic subunits vary very little from one species to another, irrespective of how their domains are structured. This highly conserved structure usually indicates that the cellular functions they perform are crucial and irreplaceable and therefore require rigid maintenance to ensure their evolutionary advantage.
In a normal human karyotype, depending on the part of mitosis the cell is in, there are either 23 or 46.
Answer:
Explanation:
Conserving the environment and preventing soil erosion, desertification, and flooding is essential. Unsustainable farming techniques not only impact natural ecosystems but also ultimately make farming itself impossible. ... Marine conservation is vital to protect human food supplies as well as marine anima
Answer:
An Enhancer
Explanation:
Enhancers are the regulatory sequences and are generally located 80-160 base pairs upstream of the transcription start site. Enhancers have bidirectional elements that are involved in the initiation of transcription. Enhancers serve as the binding sites for activators to increase the concentration of activators in the vicinity of the promoter and thereby increase the rate of transcription of the gene.
According to the given information, the loss of a regulatory sequence led to a reduced level of transcription of the gene. This means that the regulatory sequence was involved in the upregulation of transcription. The presence of the sequence far away from the promoter makes it an enhancer.
Answer:
A pH indicator is able to tell what level of pH the substance is at. It can tell how acidic a substance is. If a substance has more hydrogen ions than hydroxide ions then it is acidic. If it has more hydroxide ions that hydrogen ions it is an akaline. the acidic scale is from 0 to 14. lower numbers means more acidic and higher numbers means it is an alkaline.
Explanation:
pH stands for potential Hydrogen.
