Activation energy is required to start a chemical reaction. Activation energy is the energy needed to allow the reactant to react. Activation energy is measured in Joules (J).
        
             
        
        
        
A simple or closed fracture does not break the skin. This is further explained below.
<h3>What is a closed fracture?</h3>
Generally, a closed fracture is simply defined as a situation whereby the skin hasn't been damaged, even if the bone is cracked.
In conclusion, If the fracture is simple or closed, no blood will be seen on the skin. More detail about this is provided below.
Read more about closed fracture
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Elevation (it uses different colors to show the elevation of different places such as plains and mountains)
        
                    
             
        
        
        
The statement is once the enzyme binds to the specific substrate molecule, structural changes can occur in the active  site to accommodate the product.