Answer:
I think one thing Steinbeck is trying to get his readers to understand is that people need each other, even if the relationships may not fit the conventional paradigm that society might expect.
Explanation:
George and Lennie are the obvious example here. One man is short and "street-wise", while the other man is huge and simple-minded. All the same, the two men need each other, compliment one another (one provides "the brains", the other provides "the brawn"), and share a common dream.
Do a person is running from the police they have to hide in the woods and they do not get caught the end!!
Pandora is a goddess (if we're talking about the same Pandora) and she's the goddess of misfortune. I would assume that the political cartoon would be showing that whomever was "running" for whatever position was a mistake.