<span>Blockage of the Cerebral Artery can reduce blood supply to the brain, causing a stroke (Ishcemic Stroke)
Blood is carried to the brain by two pair of arteries, i) The Internal Carotid arteries, ii) The Vertebral arteries.
Stroke is a neurovascular condition affecting blood vessels in the brain. There are two types of Stroke i) Ischemic Stroke ii) Hemorrhagic Stroke.
In Ischemic stroke occlusion of a cerebral artery causes the damage to brain tissue dependent on blood supply from the affected vessel</span>
Explanation:
Gel electrophoresis is one simple and cheap laboratory technique used in profiling. In this case, it can be used to identify Great White Sharks using their proteins or DNA. This way, even if the fish is completely mutilated into the meat, the species can still be identified helping policies to be enforced.
DNA or proteins of a sample of suspected meat is processed and passed through gel electrophoresis. The bands that form are then compared with a standard to check if the bands match. A match indicates that the meat is from a Great White Shark.
* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies.
<span>There are indeed three ways to activate the complement:</span>
Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
