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Vera_Pavlovna [14]
3 years ago
7

The idea that, when life originated on earth, a macromolecule other than dna served the role of information storage and that thi

s same macromolecule carried out catalysis is called the _____ hypothesis.
Biology
1 answer:
svet-max [94.6K]3 years ago
4 0

The RNA world hypothesis states that the earlier life-forms had relied only on RNA (Ribonucleic Acid) for the purpose of catalyzing the chemical reactions, and storing the genetic information. This hypothesis was proposed by Leslie Orgel, Carl Woese, and Francis Crick.

This hypothesis states that long before the living forms evolved to use DNA as the genetic storage material, the RNA molecules served the purpose of both storing the genetic information and carrying out catalysis, but because of its instability, DNA evolved.

Hence, the answer is RNA world hypothesis.

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(2) epigenetic silencing at the promoter of the gene, resulting in reduced transcription.

To check for changes in the epigenetic landscape of the promoter, you could perform chromatin immunoprecipitation by extracting the chromatin from the tumour cells and using antibodies for different chromatin marks to see what has changed between the normal cells and the tumor cells. E.g. H3K9me3, H3K27me3. You would perform a pull down with the antibody of interest and then PCR for your promoter to specifically look at changes at that gene compared to normal cells. To test DNA methylation, you could perform bisulfite sequencing.

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Answer:

I think it is the variable.

Explanation:

3 0
3 years ago
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