The Silk Road was established during the HAN DYNASTY of China. The Han Dynasty opened trade with the West beginning the Silk Road. The term "Silk Road" was coined by Ferdinand von Richthofen a German geographer and traveler.
The economical boost of selling of cotton lead to the cotton gin being created during this period of time. Unfortunately, more cotton being produced meant more slaves being needed.
The answer is choice 4 "the purchase of the Louisiana Territory from France could lead to war with Spain"