Holmes said to Watson "My dear doctor, this is a time for observation, not talk, because it was part of his method to observe closely and then to consider his observations. The correct answer is A.
Answer:
The correct insulin pathway is described as under:
2. Binding of insulin to the alpha subunit of the insulin receptor
8. Activation of insulin receptor tyrosine kinase
3. Phosphorylation of IRS proteins
6. Phosphorylation of phosphinositide 3-kinase (PI-3K)
4. Conversion of PIP2 to PIP3
7. Activation of PIP3-dependent protein kinase B (PDK1)
5. Glut4 receptors transported to the cell membrane
Explanation:
The insulin signaling pathway is described as under:
RTK (receptor tyrosine kinases) which is a receptor for insulin is an extracellular receptor but in contrast to other cell surface receptors it is catalytic in nature. In the absence of insulin (ligand), it is monomeric but as soon as it gets activated (activation occurs upon ligand binding), it undergo dimerization. It leads to auto-phosphorylation in it's tyrosine residue which subsequently leads to phosphorylation of tyrosine residue of other receptors. Such hyper-phosphorylated receptor have high affinity with enzyme/molecule like IRS protein which have SH2 domain . IRS down stream activates phosphinositide 3-kinase (PI-3K). This enzyme converts component of animal cell membrane PIP2 into PIP3. PIP3 also remains membrane bound but it has the potential to phosphorylate another enzyme named as PIP3-dependent protein kinase B (PDK1). Further, PDK1 leads to the activation of Akt or PK-B. Akt is a serine-threonine kinase which ultimately leads to the recruitment of Glut4 receptors on cell membrane for uptake of more and more glucose into the cell.
Note: Apart from this Akt also phosphorylates another protein named as FOXO which ultimately causes cell growth, Akt can also phosphorylate BAD protein so as to restrict cell apoptosis or we can say it leads to cell survival, Akt also leads to translation in a cell with the help of mTOR raptor etc.
The relationship between its volume and surface area limits how large a cell can get.
<h3>What is cell range?</h3>
The range of a cell is defined as the quantity of material that can be found within a cell with respect to the surface area.
The range of a cell is limited by the volume and the surface area which means that the wider the surface area the more volume the cell can contain.
Learn more about cell here:
brainly.com/question/13920046
#SPJ12
I would say D. small intestine
If you want an explanation, here it is
After leaving the stomach, water is absorbed mostly in the early segments of the
small intestine, the duodenum, and the jejunum. A small portion of all water absorption occurs in the stomach and the colon: the small intestine absorbs 6.5L/day, whereas the colon absorbs 1.3L/day.
