Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
To confirm the above hypothesis, Maria should perform an experiment to prove that xylem is responsible for the transport of coloured water through the plant. This is called the ascent of sap.
A suitable plant having a tender, semitransparent stem should be selected. The root system of the plant should be cut off and the twig has to be placed half-immersed in a coloured solution of water for about one hour. Later, when the plant is observed, parallely running streaks of coloured water can be seen through the semitransparent stem and other parts of the plant indicating that the xylem is involved in the upward movement of water.
It's B
Explanation:
Because the fossil record shows how organisms have evoluate from relatively simple organisms to more complex organisms
Answer:
DEC = CC + CF
Explanation:
It should be understood that, the concentration profile across the endothelial cells will base on the diffusion rate of the filtrate .
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