A rise or fall in the pH of the medium from the optimum of pH 7 usually affect the enzymes' active sites of and therefore the shape and the rate of enzyme activity.

Assuming the pH is too low, the enzyme medium becomes acidic;Acidosis. The high Hydrogen ions concentration interacts with the R-groups of the amino acids moiety of the enzymes, this interaction affects the ionization of the R-groups, disrupting the ionic bonding holding these R-groups in shape.

This results in loss of the 3-Dimensional shape arrangements of the protein molecule and therefore of the active sites. Since active sites of enzymes determines the specificity of the enzymes substrate- complex to give enzyme-product complex, the catalytic activity of the enzymes decreases, the rate of reaction decreases,and products formation stops, and the reaction also stops.

The same is applicable to extremely high pH=Alkalosis.

However, the effective buffer system of the body prevents this scenarios from happening in real sense in the body. Through mopping by the haemoglobin, excretion by the kidney, etc

7 0

3 years ago

A fast-flowing river of air that forms when two air masses of very different temperatures meet is called a

Ulleksa [173]

A fast-flowing river of air that forms when two air masses of very different temperatures meet is called a jet stream :)

5 0

3 years ago

Read 2 more answers

Which pharmacokinetic parameter is affected most by decreased intestinal motility related to the aging process? a. excretion b.

Tpy6a [65]

I believe the answer is c. absorption

The phase of pharmacokinetic that happens in the intestine is when the drug absorbed. A person with old age will have lower intestine motility. This will increase the transit time which will increase the amount of drug absorbed.

Age could also influence others pharmacokinetic parameter(excretion, distribution, metabolism) but it is related with another organ, not intestine.

8 0

3 years ago