Answer:
Validity is the degree to which the research measures what it has to measure. High validity = Proper Research Design.
Reliability is the measure to which research measurement techniques are free of error or mistakes. High realiability = Reasearchers know the sample fully understands the question asked.
Representativeness is the extent to which consumers in a study are similar to the larger group of interest. High representativeness = Sample is large and chosen in an unbiased way.
Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Go in front of the mirror and act like robot and talk ,there you have a robot voice like real human voice
Depends What type of Hardware you are talking about there it depends what you upgrade in a computer for example if you upgrade your ram it make it run and preform faster.