First pass metabolism of a drug is said to occur when the concentration of a drug that is administered orally is significantly reduced before it reaches the systemic circulation.
First pass metabolism usually occur in the liver.
The routes of drug administration that avoid complete first pass metabolism are: sublingual, transdermal, rectal and inhalation.
The answer is going to be B .
a. that are all affected
Since the father is homozygous dominant (AA), and he is affected, that means that the disorder (or whatever it is), is autosomal dominant (plus it directly tells you that). That means it is not carried on the sex chromosomes. Since every child he has will inherit one of his alleles, they will all be affected by having at least the one.
B. Resistance is the tendency for materials to oppose the flow of electric charges.
