Answer:
The Holy Roman Empire faced many territorial challenges.
Explanation:
The first challenge was in Italy: the Italian states that were part of the Holy Roman Empire were separated from the German hinterland by the Alps, which imposed a communication barrier that made it very difficult for Emperors to hold control over these lands.
In what is now Germany, there were also territorial issues. The land was divided among countless states: duchies, counties, princedoms, fiefdoms, city-states, and so on, something that made coordination at the imperial level very difficult.
As centuries passed, the Holy Roman Empire lost control over several possessions: it lost most of the Low Countries, and the Italian city-states like the Duchy of Milan and the Republic of Venice became fully independent.
Answer:
The relationship was improving.
The relationship provided increased leverage with the Soviet Union.
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Answer:Smallpox and vaccination are intimately connected. Edward Jenner developed the first vaccine to prevent smallpox infections, and this success led to the global eradication of smallpox and the development of many more life-saving vaccines.
Explanation:
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