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madam [21]
3 years ago
6

Which of the following events normally activates a GTP-binding protein?a).GTP hydrolysis by the protein Activation of an upstrea

m GTPase-activating proteinb).Activation of an upstream guanine nucleotide exchange factorc). Phosphorylation of a bound GDP molecule by an upstream phosphorylased). Pi release after GTP hydrolysis
Biology
1 answer:
olya-2409 [2.1K]3 years ago
8 0
<h3><u>Answer;</u></h3>

b). Activation of an upstream guanine nucleotide exchange factor

<h3><u>Explanation</u>;</h3>
  • <em><u>When a ligand activates the G protein-coupled receptor, it induces a conformational change in the receptor that allows the receptor to function as a guanine nucleotide exchange factor (GEF) that exchanges GDP for GTPthus turning the G protein-coupled receptor on.</u></em>
  • The activated G-protein then dissociates into an alpha (G-alpha) and a beta-gamma complex.
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