It nearly became extinct by a combination of commercial hunting and slaughter in the 19th century and introduction of bovine diseases from domestic cattle. With a population in excess of 60 million in the late 18th century, the species was down to just 541 animals by 1889.
The Indian Removal act was harsh because many native Americans were forced out of their homes and to a small are when they actually were supposed to own all of it. Another reason it was harsh was because many of them died because of no food, poor living conditions and some of the were simply not fit to make the move.
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They allowed Portuguese and Spanish navigators to sail across oceans rather than only along the coast.
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