Aliskiren was added to enalapril in individuals with chronic heart failure, however there was no improvement in the side effects in hypertension. In comparison to enalapril, noninferiority was not demonstrated for aliskiren.
Antihypertensive medications like enalapril have varying effects on blood pressure regulation, so for a synergistic effect, these medications are typically combined. Ninety percent of hypertension patients have an unknown underlying etiology. As a result, the primary function of antihypertensive medications such as enalapril is to change the body's regulatory systems (such as the renin-angiotensin-aldosterone system and baroreceptors) in order to maintain normal blood pressure. Enalapril at a dose of 5 or 10 mg twice daily for 2336 patients, aliskiren at a dose of 300 mg once daily for 2340 patients, or both therapies for 2340 patients of hypertension, to one of three groups (combination therapy). Heart failure hospitalization or death from cardiovascular causes made up the majority of the composite outcome in hypertension.
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Answer:
A key Symptom of REM sleep disorder is (b) the occurnace of motor movements during slow-wave sleep.
Explanation:
Lots of movements can occur such as kicking, punching or jumping off the bed.
Micheal might be suffering from diabetes insipidus.
Diabetes insipidus
Diabetes insipidus is a condition in which the affected person has the urge to pee a lot and feels thirsty all the time. Even though it is not directly related to diabetes, it is named as such because the affected person has symptoms similar to diabetes. The two main symptoms are polydipsia and polyuria.
Cause of Diabetes insipidus
Diabetes insipidus is caused by the lack of production of antidiuretic hormone (ADH). ADH is produced by the hypothalamus which then gets stored in the pituitary gland. When the person was subjected to surgery to remove the entire mass of cancer cells in the pituitary gland, the ability of the gland to store ADH could have been lost.
The ADH allows the retention of water by concentrating the urine. In a person with diabetes insipidus, the production of AHD is affected, and in very rare cases the response by the kidneys to ADH is reduced which also reduces the water reabsorption and increases urine volume.
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