Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
anything that could escalate
Explanation:
what are the choices? i would think that you keep your temper very low do not raise your voice and try to get them into a seperate room so that you can try to calm them down
For question 1:
Look at the graph. In the beginning we start out with a feed of 75% wheat and 25% corn. The weight of the pig is 40. Look at the rest of the graph. Each time they lessen the amount of wheat the pigs eat and add more corn, they get heavier. By the end, the pigs are fed a blend of 25% wheat and 75% corn and they weigh 61 pounds. The answer would be C.
Answer:
b. cladophora
Explanation:
The cladophora algae is a type of green algae that grows attached to rocks or wood that are underwater. It forms short, rigid green filaments that branch, it's smell is similar to mushrooms. The cladophora is introduced in aquariums via contaminated plants or equipment, therefore to prevent it's formation it is necessary to clean everything before intoruducing it to the aquearium. This algae is so resistant once installed that usually the tank has to be re-started.
The population of scavengers would increase.
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