OBJECTIVES: To analyze the occurrence and types of neoplasias that have developed in patients submitted to orthotopic heart transplantation in the Cardiac Transplantation Program of the Paulista School of Medicine, Federal University of São Paulo.
METHODS: The present study presents an observational analysis of 106 patients submitted to orthotopic heart transplantation from November 1986 to September 2002, who survived for more than 30 days after the procedure. The immunosuppressive regimen consisted of triple therapy with cyclosporin A, azathioprine and corticosteroid. Only two patients received, in addition to triple therapy, the addition of orthoclone OKT-3. The mean follow-up period was 61.4 months. (variation from two months to 192 months).
RESULTS: Twenty-three patients (21.3%) developed neoplasias, of which 56.5% had skin neoplasms, 30.1% had solid tumors and 13.4% had post-transplantation lymphoproliferative disease (PTLD). The mean interval between transplantation and the diagnosis of neoplasia was: skin - 54.9 months, solid tumors - 24.8 months and DLPT - 70.3 months.
CONCLUSIONS: The occurrence of malignant neoplasms was relatively common in the analyzed population. Skin cancer prevailed in relation to other neoplasms and solid tumors were more diagnosed than lymphoproliferative diseases in this series of patients.
Mrs. Hale is the most sympathetic to Minnie Wright because she knows about Minnie's unhappy marriage to Mr. Wright. Her sympathy is also evident when Mrs. Hale asks Mrs. Peters to lie to Minnie about her preserves. Mrs Hale tells Peter, " If I was you, I wouldn't tell her her fruit was gone. Tell her it ain't. Tell her it's all right. Take this in to prove it to her. She—she may never know whether it was broke or not."
Is this short enough?
Simile- <span>My phone slipped through my fingers like butter
Personification- </span><span>The face of my phone had many scars from being dropped
Symbol- </span><span>My phone is my lifeline to the world</span>
Local Color Writing - is fiction and poetry that focuses on the characters, dialect, c<span>ustoms, t</span><span>opography,</span> and other features particular to a specific region.
The denotative definition of a word is its literal meaning. This would be the meaning one would find in the dictionary.
By contrast, the connotative definition is the meaning associated with the word. It is the implied meaning of the word.
For example, the words in bold have the same denotation but different connotations:
-- a beautiful woman
-- a handsome woman
-- a pretty woman
While all these words mean the same thing, they do not have the same associations.
