Answer:
CD40L
Explanation:
The CD40 ligand (CD40L) protein is a transmembrane glycoprotein which is expressed on activated T cells and belongs to the tumor necrosis factor (TNF) superfamily. The hyper IgM syndrome is caused by mutations in the CD40L gene, where the defective protein can no longer bind CD40 on antigen-presenting cells. The X-linked Hyper IgM syndrome is characterized by abnormal levels of immunoglobulins, i.e., low levels of IgG and IgA, and increased/normal levels of IgM. Because CD40L gene is located on the X chromosome, this disorder is observed much more frequently in males than in females.
Do you have a graph or something that shows the results of the trial. or just more detail?
Answer:
Simply put your hand out and block them and put them back in the corner in a sit position. make sure that you let your dog know that not moving is what gets them. The reward gradually increase the distance and time as we did in the corner until they can stay for 10 seconds at 10 feet away.
Also, with a leash, when teaching your dog to stay, say "stay" and pull the leash back to when the dog is sitting. This gives the dog an understanding of what to do and how to do it. Repeat this a few times. Then the dog will learn to sit and stay before the leash stops. Then they will have learned the "Stay" command.
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