A major reason was that he wanted them gone from the land and they didn't want to move. He believed that the US had to go westwards while the Natives didn't want to go away from their land. This is after he signed the Indian Removal Act. Cherokee were one of the tribes that didn't want to relocate, and what happened later is history.
They started selling tobacco.
Explanation:
Most of the slaves held by West Africans in the late 1800s used to grow food crops. The chapter of slavery in America started in 1619 when 20 salves were brought by the The White Lion in Virgina.
In the 17th and 18th centuries, black slaves worked basically on the tobacco, rice, and indigo plantations of the southern coast, from the Maryland and Chesippe Bay colonies to Georgia in the south.