The extension of slavery into the western territories.
For a specific instance, see the landmark supreme court case Dred Scott v. Sandford.
Disadvantages, I believe, but am not sure are factual, were with a strong executive branch, the people feared that the president would manipulate his powers, just like the king of England had done so with the colonies and those who disagreed with it thought that the smaller sates wouldn't be voiced.
Answer:
locke poined the ideas of natural law, social contract, religion toleration, and the right to revolution that proved essential to both the amarican revolution and the U.S constitution that followed
