Answer:
Constitutive activation is the alteration of a protein or signaling pathway such that it is functional or engaged even in the absence of an upstream activating event. For example, RasD is constitutively active because it cannot bind GAP and therefore remains in the GTP-bound, active state even when cells are not stimulated by growth factor to activate a receptor tyrosine kinase.
Constitutively active Ras is cancer promoting because cells will proliferate in the absence of growth factors, and thus normal regulatory mechanisms for cell proliferation are bypassed.
(a) A mutation that resulted in Smad3 binding Smad4, entering the nucleus, and activating transcription independent of phosphorylation by the TGFβ receptor would render Smad3 constitutively active.
(b) A mutation that made MAPK active as a kinase and able to enter the nucleus without being phosphorylated by MEK would render MAPK constitutively active.
(c) A mutation that prevented NF-KB from binding to IK-B or that allowed NF-KB to enter the nucleus and regulate transcription even when bound to IK-B would render NF-KB constitutively active.
Answer:
yeah of course but sometimes they annoy you so much that you'll end up hating her but inside you love hey more than anyone in this world ❤️
Answer: control plot
Explanation:
Control plot refers to the plot that couldn’t receive the experimental treatment such as fertilizer and or variable being tested while another plot receive fertilizer can give proper yield. It is just because, fertilizer is the main source or substance that provides chemical elements that may necessary for corn plant growth and its development. There are two main types of fertilizers such as organic and inorganic, among them organic fertilizer usually contains different nutrients that broken down by different microorganism and then used by such plants to grow effectively.
Answer:
D variations in individuals are not heritable
Explanation:
Genetic variation in individuals is what drives evolution. In a population of individuals in an environment, with the adequate resources, overpopulation can occur. However, resources are usually a limiting factor for population growth: there is not sufficient food/shelter etc. for everyone to survive.
Some individuals are better suited to success in the environment. This is because of random variation in their DNA that has arisen that give them a selective advantage. This allows them to thrive, take advantage of the limited resources over other members of the population, and be more likely to survive to reproductive age. This is natural selection.
Because this variation is genetic (in the DNA), they can then pass it on to their offspring. Over time, this leads to evolution over time.
If a nurse suspects that a newly admitted infant is the
victim of child abuse, the following parental behaviors might support the
diagnosis of child abuse:
1. The parents focus on the child's role in sustaining the injury<span>
2. The parents are changing the account
of how the injury occurred
<span>3. Their explanation of how the
injury was sustained is not consistent with the injury</span></span>
