Answer:
Leptin is a protein hormone composed of 167 amino acids of the cytosine family, it is synthesized mainly by white adipose tissue. The leptin receptor is related to that of receptors for cytosines (since it uses Janus or JAK type kinases and STAT-3 proteins as intracellular mediators of transcription pathway), it is predominantly found in the hypothalamus (particularly in the arcuate nucleus and to a lesser extent in the nuclei dorsomedial and ventromedial), hippocampus and cerebellum. There is evidence that leptin acts at the level of the arcuate nucleus, preventing the formation of NPY.
Explanation:
Leptin is produced exclusively in adipose tissue cells in a wide variety of species, including humans, and its concentration is higher in overweight than in lean individuals. The biological actions of leptin can be classified into two groups, those that are exerted in the tissues of the central nervous system, mainly the hypothalamus, and those that are carried out on the peripheral tissues. The former regulate body weight downward, decrease food intake, increase basal energy expenditure and modify some neuroendocrine functions such as reproduction, while the latter have effects on proliferation, differentiation and metabolism of peripheral tissues. The leptin that reaches the hypothalamus, in addition, inhibits protein synthesis and the secretion of neurons producing NPY / AgRP of the arcuate nucleus and stimulates the synthesis and secretion of those containing POMC. NPY (neuropeptide Y) is produced in the hypothalamic arcuate nucleus. This neurotransmitter arrives through the projections of the neurons of said nucleus to the paraventricular nucleus, which is the area where it is released. There are several studies that have shown that an increase in NPY leads to an increase in the sensation of hunger and thus to hyperphagia and obesity. Leptin acts at the level of the arcuate nucleus, preventing the formation of NPY. The leptin receptor lacks enzymatic activity in its intracellular domain. Instead, it is linked to members of the janus kinase family, which belong to a class of tyrosine kinases. The binding of the ligand activates the Jak kinase and leads to the phosphorylation of certain cytoplasmic proteins. Within these proteins there is a class of cytoplasmic transcription factors called signal transducers and activators of transcription (STAT).
Answer:
Light takes 499.0 seconds to travel from sun to earth.
Explanation:
Climate change refers to significant changes in global temperature, precipitation, wind patterns and other measures of climate that occur over several decades or longer.
The seas are rising. The foods we eat and take for granted are threatened. Ocean acidification is increasing. Ecosystems are changing, and for some, that could spell the end of certain regions the way we have known them. And while some species are adapting, for others, it’s not that easy.
Evidence suggests many of these extreme climate changes are connected to rising levels of carbon dioxide and other greenhouse gases in the Earth’s atmosphere — more often than not, the result of human activities.
Climate change, therefore, is a change in the typical or average weather of a region or city. This could be a change in a region's average annual rainfall, for example. Or it could be a change in a city's average temperature for a given month or season. Climate change is also a change in Earth's overall climate.
Hope this helps you:)
Answer:
Minimal media + glucose + streptomycin
Explanation:
Those capable of synthesizing galactose can grow in minimal media, the availability of streptomycin will destroy those who are susceptible to the antibiotic, whereas glucose, a carbon source from which galactose may be produced and will encourage growth.
Therefore:
The medium should not include galactose when selecting for gal⁺.
Streptomycin should be present in the medium to select against 
.
The medium to choose is: Minimal media + glucose + streptomycin.
Answer: "A muscle cramp is a sudden and involuntary contraction of one or more of your muscles"
Explanation:
