The correct answer of the given question above would be the last option. The author's choice of words affects the tone of the excerpt in a way that the words candor and legacy impart a complimentary tone. Candor means being open or honest. And these two words impart a flattering tone.
You could do Coyote and Wishpoosh, and look up the myth on Google.
Answer:
Some viruses are doctors' inventions.
Newer drugs inventions by the doctors, has really contributed positively on the global economic growth.