It was significant because at the
time we were divide between a strong national government or a nation of states whom ran themselves
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The secession of Southern States led to the establishment of the Confederacy and ultimately the Civil War. It was the most serious secession movement in the United States and was defeated when the Union armies defeated the Confederate armies in the Civil War, 1861-65. Hope this helps, good luck! :)
The progressive era brought significant reforms to American industrial capitalism and to the American political system, through participation and activism by ordinary Americans. The progressives had organized to improve the working and living conditions for poor people, only really to address the glaring social and environmental problems, as well as expand opportunies for democratic involvement in the political system.
The plague was spread through trade