Question

Who offered opposition to the rule of Charles V

Answer 1

Martin Luther of Germany, he generated a schism in the Catholic Church and formed his own Lutherism faction of Christianity. 

Hope I helped :) 

Answer 2

Answer:

Martin Luther.

Explanation:

He began the Protestant ideals, in Germany. He's main claims was to the Church, because they weren't teaching according to the Bible. This made him to create his own Christian movements, known as Lutheranism. This problems with the Catholic Church represented a problem to Charles V, because he was the Holy Roman Emperor, which means he was handed with the Catholic Church.