One of the clearest policy manifestations of the "kill the Indian, save the man" concept in western expansion would be those of the boarding school era. These policies removed Native American children from their homes and sent them to far-off boarding schools in an effort to replace (and remove) Native languages, customs, and culture from an entire generation. White policymakers waged a cultural genocide on the generation in an effort to replace their Native traditions with English, Christianity, and other white, Euroamerican values. The earliest boarding schools were actually created by William Pratt, the military official who first coined the "kill the Indian, save the man" motto.
They were mainly agriculture based and slavery was free labor.
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The expansion to conquer China for raw materials and the alliance with Germany and the threat of Russia lead to WW2
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They lose outta business.
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Pierre Le Moyne founded the French colony of Louisiana and the first European settlement in what is now Mississippi at Biloxi in 1699.