Researchers discovered a strain of C. parvum that expresses a functional variation of the lactate dehydrogenase gene. A DNADNA s
equence comparison showed that the variant differs from the normal sequence in the region that codes for the enzyme’s allosteric site. Predict the effect of FX11FX11 treatment on C. parvum cells that express this variant of lactase dehydrogenase. Provide reasoning to support your prediction. Explain how gossypol and FX11FX11 might be used as drugs to treat C. parvum infections in humans without negatively affecting human cells.
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Answer:
the question is incomplete, the graph is attached and the requested question is answered
The affinity of the inhibitor will be affected when the allosteric site is affected or changed, for which more information is required, however the change will reduce the affinity and the FX11 structure will not be effective when inhibiting the growth of C. parvum, an inhibitor it can return to the allosteric site since it contains characteristics that allow it to mate, however if these structures change their conformation, the inhibitor will not be able to bind and the affinity will decrease.
This system can be used to generate medications, however the pathway by which the parasite is going to attack interrupts the lactic fermentation and is located in the digestive system of the nospedero, in these organs there is a decrease in aerobic respiration, in these conditions it is can affect muscle tissue, so one of the recommendations is to avoid physical activity while taking the drugs
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