Answer:
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He feared that the issue of slavery would destroy the nation. In the speech the "House" he speaks of represents the nation, the US, and he feared they would become divided over slavery.
Poor hygiene, and pest infestations and people living close to each other.
Of course, back then, the church wanted people to believe it was "DA JEWS SPREADIN THEIR SATAN PLAGUE" but that is completely false.
It’s location on the sea made it a cultural crossroads
Explanation: The first option is the correct one because Alexander built the city on this place due to a fact that it enabled him to connect different parts of the Empire. It was a crossroad of trade, knowledge and culture and for a long time the center of Mediterranean.
Second option is not correct as during Hellenistic period Greece was not as important as it was during previous eras, especially classical period.
Third option is not correct as Alexandria is located in Africa.
Fourth option is not correct as Egypt is and was a global center and a crossroad.