Topoisomerase is the enzyme that can be added to correct the untwisting that is led to strain ahead of the replication fork.
If there's options, I assume mutation?
Rainwater picks up carbon dioxide from the air and as it percolates through the soil, which turns into a weak acid. This slowly dissolves out the limestone along the joints, bedding planes and fractures, some of which become enlarged enough to form caves.
They leave corns to grow into future oak trees
