Answer:
The correct answer is "5-1-3-2-4".
Explanation:
Internalization of LDL particles into cells, is needed to form the intracellular vesicles known as endosomes. The order of events that allow for this process are:
5) LDL receptors migrate to the cell surface and cluster in clathrin-coated pits. Clathrin acts directing the receptors to the cell membrane region where endosomes are formed.
1) A combination of cholesterol and apolipoprotein binds to LDL receptors and becomes internalized as endocytotic vesicles. Once the receptors are in the proper cell membrane region, cholesterol and apolipoprotein are bound and internalized.
3) Several endocytotic vesicles fuse to form an endosome.
2) The environment of the endosome becomes acidic, which causes the LDL to dissociate from its receptor; additionally, the endosome fuses with a lysosome. LDL should be dissociated from its receptor since it is going to be degraded in the following step.
4) The LDL particle is degraded by the lysosome. This takes place after endocytosis, when LDL particles are transported into lysosomes once they are fused, cleaving the cholesterol esters into cholesterol and fatty acids.
C. Gradual
Hope this helps!
Answer:
Nucleus
the central and most important part of an object, movement, or group, forming the basis for its activity and growth.
Nucleolus
a small dense spherical structure in the nucleus of a cell during interphase.
The effect of human activity on the amount of carbon stored in sinks is that humans are pulling out the carbon and burning it at a fast pace through activities like mining. The has greatly contributed to the effects such as global warming. I therefore, think that humans are supposed to seek for alternate sources of energy to prevent these effects of global warming.
