It was in 1837 when John Deere, a blacksmith from Illinois invented a steel mouldboard plough that was strong enough to cut through the stubborn roots of the prairie grasses. This invention turned millions of acres of prairie land into fields for arable crops and grazing ground for huge herds of domesticated cattle. The starving Indians who were displaced resorted to slaughtering the bison in 1872 to 1874 that resulted in the decrease of its population from 7.5M animals to about 750 only.
The previous statement is true because if a substance cannot get into a cell membrane it is assisted via protein channels however if it doesn't need the protein channels then it just flows through the membrane.