Question

In a person with MCAD deficiency, if the body has excess glucose stores, which electron transfer intermediates are likely to accumulate? How does this change if the body is energy depleted?

Answer 1

Answer:

In high glucose-NADH and FADH2

In depletion case- NAD+ and FAD+2.

Explanation:

MCAD (Medium-chain acyl-CoA dehydrogenase) deficiency may be defined as inherited disorder in which the body's ability to breakdown the fat decreases and converting them in energy.

Excess glucose stores: The presence of excess glucose prevents the proton gradient to transfer electrons in the electron transport chain. This causes the buildup of NADH and FADH2.

Low energy state: This state needs ATP that decrease the carriers and causes the buildup of NAD+ and FAD+2.