A female candidate (Sarah Palin) was running for vice president, but this was not the first time, for example Geraldine Ferraro run for vice president in 1984.
It was significant because It marks the first time a major political party has nominated an African American for its presidential candidate. This candidate also later won and is today's president!
Answer:
The slaves didn't have rights to vote
Explanation:
The white people owned the black's, so they limited any rights for them.
There wouldn't be a USA, and...
the Indians would still have pretty much all of the Middle-west of the USA.
Hawaii would still be under their kings/queens
Alaska would still be part of russia
China would pretty much never had any technological progress (they isolated themselves)
Japan would still be going around with pretty much katanas.
etc etc
if you want more i can give you more (if you want information on why one is on the list, post it in the comments)
hope this helps