Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
The answer is rain percolates through the pavement into the ground below, causing cracks in the pavemen
There are four environments on Earth that are called spheres: hydrosphere, lithosphere, atmosphere, and biosphere.
<h3>Features associated with each of Earth's four spheres.</h3>
<h3>Hydrosphere </h3>
It is the set of all the water on the planet, including those that form clouds.
<h3>Lithosphere</h3>
The continuous part of our planet, made up of rocks and soil. The most superficial part is called the earth's crust.
<h3>Atmosphere</h3>
It is the gaseous sphere that surrounds our planet, composed mainly of gas oxygen and gas.
<h3>Biosphere </h3>
It is the part of our planet that can support life
<h3>Internal processes</h3>
The atmosphere and hydrosphere are the main regulators of the planet's climate. Without both, the temperature changes would be very sudden: at night it would drop to minus 150°C and during the day above 100°C, making life on Earth difficult.
With this information, we can conclude that the spheres of the earth, support life, and make the planet earth unique.
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